The extraction known as IDS 89 (Strogen®) is able to inhibit 5α-reductase in vitro with an IC 50 of 2,200µg/mL when tested in whole prostate homogenates, while having some efficacy at 500µg/mL in both epithelial and stromal prostate cells. There is another extract known as Permixon® which is an n-hexane extract lipodo/sterolic extract of the fruits. Supercritical CO 2 extracts are one of the basic forms of saw palmetto extracts. This particular extraction, in contrast to the raw berries, has certified concentrations of phytosterols (campesterol, β-sitosterol and stigmasterol), carotenoids (46.8μg/g as β-carotene), and vitamers of Vitamin E (gamma and delta tocopherol at 280μg/g and 35.3μg/g). dodecanoic) and oleic acid with some myristic acid and palmitic acid as the next major components. This extraction increases process the amount of fatty acids as triglycerides relative to the ground fruit (by 6-25 times ) and is composed predominately of the unsaturated fatty acids lauric (aka.
![saw palmetto saw palmetto](https://m.media-amazon.com/images/I/81gP4d+3NCL._AC_SL1500_.jpg)
Sabalselect® is similar to the National Institute of Standards and Technology's reference material SRM 3251, which is extracted using a similar procedure. Supercritical CO2 extracts of saw palmetto, also known under the brand name Sabalselect®, tend to have a high percentage of unsaturated fatty acids (84%) with lower amounts of fatty acid esters (10%) and less than 2% of other chemical components (phytosterols, aliphatic alcohols, and polypyrenic compounds). Saw palmetto bioactivity tends to be concentrated in the fat-soluble components of the berry. Anti-5α-reductase activity is found in the lipid soluble extracts of the fruits, with more potency in the saponifiable subfraction. The mechanism of action that saw palmetto is most known for is inhibition of the enzyme 5α-reductase, which is responsible for converting testosterone into its more androgenic form, dihydrotestosterone (DHT). Saw palmetto contains numerous fatty acids, mostly in triglyceride form, and phytosterols.
#Saw palmetto free
In general, most of the fatty acids in saw palmetto exist in triglyceride form over the free fatty acid form. Stigmasterol (a phytosterol) at 0.0477☐.0020mg/g dry mass Β-Sitosterol (a phytosterol) at 0.454☐.018mg/g dry mass Tetracosanoic acid (C24:0) (lignoceric acid) 0.0107☐.0003% dry mass as triglycerides and 0.0960☐.0033mg/g as free fatty acids Ĭampesterol (a phytosterol) at 0.1175☐.0025mg/g dry mass Docosanoic acid (C22:0) (behenic acid): 0.0066☐.0002% dry mass as triglycerides and 0.0564☐.0050mg/g dry mass as free fatty acids
![saw palmetto saw palmetto](https://npr.brightspotcdn.com/dims4/default/fc8b600/2147483647/strip/true/crop/911x561+44+0/resize/880x542!/quality/90/?url=https%3A%2F%2Fmedia.npr.org%2Fassets%2Fimg%2F2011%2F09%2F28%2Fsawpalmetto_wide-66ebbbcd0ff89b44e9a6e5730775a79bf3c0729a.jpg)
Eicosanoic acid (C20:0) (arachidic acid): 0.0097☐.0002% dry mass as triglycerides and 0.1455☐.0076mg/mg dry mass as free fatty acids (Z,Z)-9,12-Octadecadienoic acid (C18:2 n-6) (linoleic acid): 0.824☐.055% dry mass as tryglycerides and 5.70☐.48mg/g dry weight as free fatty acids (Z)-11-Octadecenoic acid (C18:1 n-7) (vaccenic acid): 0.0547☐.0030% dry mass as triglycerides and 0.789☐.053mg/g dry mass as free fatty acids Octadecanoic acid (C18:0) (stearic acid): 0.1791☐.0054% dry mass as triglycerides and 2.023☐.094mg/g as free fatty acids Heptadecanoic acid (C17:0): 0.0061☐.0007% dry mass as triglycerides and 0.0926☐.0060mg/g as free fatty acids
![saw palmetto saw palmetto](https://naturestruth.com/wp-content/uploads/2015/04/saw-palmetto.png)
(Z)-9-Hexadecenoic acid (C16:1 n-7) (palmitoleic acid): 0.0158☐.0010% dry mass as triglycerides and 0.216☐.014mg/g dry weight as free fatty acids Hexadecanoic acid (C16:0) (palmitic acid): 0.869☐.027% dry mass as triglycerides and 8.72☐.45mg/g dry mass as free fatty acids Pentadecanoic acid (C15:0): 0.0047☐.0006% dry mass as triglycerides and 0.0121☐.0009mg/g dry weight as free fatty acids Tetradecanoic acid (C14:0) (myristic acid): 1.103☐.007% dry mass as tryglycerides and 5.96☐.21mg/g dry mass as free fatty acids Tridecanoic acid (C13:0): 0.0076☐.0014% dry mass as trglycerides and 0.0165☐.0011mg/g dry mass as free fatty acids Octanoic acid (C8:0) (caprylic acid): 0.1072☐.0027% dry mass as trigycerides and 0.781☐.036mg/g dry mass as free fatty acids ĭecanoic acid (C10:0) (capric acid): 0.1175☐.0055% dry mass as triglycerides
#Saw palmetto full
Two of the main bioactive fatty acids (see the rest of the Full Summary for details): (Z)-9-octadecenoic acid (C18:1 n-9) (oleic acid) at 3.24☐.15% dry mass as triglycerides and 33.7☑.9mg/g dry mass as free fatty acids, and dodecanoic acid (C12:0) (lauric acid) 2.962☐.062% dry mass as triglycerides and 7.21☐.036mg/g dry mass as free fatty acids The ground fruits of saw palmetto, referenced as SRM 3250, have the following composition:
![saw palmetto saw palmetto](https://cdn.buddhateas.com/media/catalog/product/optimized/5/d/5dca6bee1a12eeb16c62f147956d0ebc/saw-palmetto-_rev004__front_1.jpg)
'Saw palmetto' refers to the berries from the dwarf palm tree known as American Serenoa repens which have traditionally been used for male fertility and libido and claimed to increase breast size in women. 1Sources and Composition 1.1Origin and Composition